semaglutide shortage 2023 Novo Nordisk's officially concludes in the US, spelling major threat for weight loss drug compounders How use of diabetes drug

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Semaglutide reaches full benefit around week 16, while tirzepatide's dual-pathway effect often produces noticeable changes by week 8-10

This requirement itself can affect side effects, as taking the tablet with food or too much water reduces absorption and can alter the side effect profile

The current findings show semaglutides impact on weight loss is even greater at higher doses

Tirzepatide achieved MASH resolution rates of 44% to 62% across doses in the SYNERGY-NASH trial (up to 73% on the efficacy estimand at 15 mg)